Intermolecular forces and interfacial phenomena are responsible of the functionality of materials, devices, and systems with novel properties and functions that are achieved through the control of matter, molecule by molecule, surface by surface or at the macromolecular level. A revolution has begun in science, engineering and technology, based on the ability to organize, characterize, and manipulate matter systematically at levels where controlling intermolecular forces becomes extremely valuable and useful to understanding complex and conventional materials. Far-reaching outcomes for the 21st century in these two areas are envisioned in both scientific knowledge and a wide range of technologies in most industries, healthcare, conservation of materials and energy, biology, environment and education. Opportunities have opened as new tools enable fundamental discoveries and technological advances. Outstanding benefits have resulted from initial studies and applications. Formidable challenges remain, however, in the areas of fundamental understanding, device design, system design and architecture, manufacturing, and system integration and deployment taking into account the intermolecular forces, interfacial phenomena, and education.